Antibiotic tolerance is associated with the failure of antibiotic treatment and the relapse of
many bacterial infections. However, unlike resistance, which is commonly measured using …

Persisters are transiently tolerant variants that allow populations to avoid eradication by
antibiotic treatment. Their antibiotic tolerance is non-genetic, not inheritable and results from …

Persisters are transiently antibiotic-tolerant cells that complicate the treatment of bacterial
infections. Both theory and experiments have suggested that persisters facilitate genetic …

Resistance of important bacterial pathogens to common antimicrobial therapies and the
emergence of multidrug-resistant bacteria are increasing at an alarming rate and constitute …

Uropathogenic Escherichia coli (UPEC) proliferate within superficial bladder umbrella cells
to form intracellular bacterial communities (IBCs) during early stages of urinary tract …

Many bacterial pathogens can permanently colonize their host and establish either chronic
or recurrent infections that the immune system and antimicrobial therapies fail to eradicate …

Bacteria have at their disposal a battery of strategies to withstand antibiotic stress. Among
these, resistance is a well-known mechanism, yet bacteria can also survive antibiotic attack …

Dormancy holds a vital role in the ecological dynamics of microorganisms. Specifically, entry
into dormancy allows cells to withstand times of stress while maintaining the potential for …

Any bacterial population harbors a small number of phenotypic variants that survive
exposure to high concentrations of antibiotic. Importantly, these so-called 'persister cells' …

Health care-associated infections present a major threat to modern medical care. Six
worrisome nosocomial pathogens—Enterococcus faecium, Staphylococcus aureus …