[HTML][HTML] Preclinical to clinical utility of ROCK inhibitors in cancer

J Barcelo, R Samain, V Sanz-Moreno - Trends in Cancer, 2023 - cell.com
ROCK belongs to the AGC family of Ser/Thr protein kinases that are involved in many
cellular processes. ROCK-driven actomyosin contractility regulates cytoskeletal dynamics …

How many kinases are druggable? A review of our current understanding

B Anderson, P Rosston, HW Ong… - Biochemical …, 2023 - portlandpress.com
There are over 500 human kinases ranging from very well-studied to almost completely
ignored. Kinases are tractable and implicated in many diseases, making them ideal targets …

Role of RhoA and Rho-associated kinase in phenotypic switching of vascular smooth muscle cells: Implications for vascular function

T Sawma, A Shaito, N Najm, M Sidani, A Orekhov… - Atherosclerosis, 2022 - Elsevier
Cardiovascular disease (CVD) continues to be the primary cause of global mortality.
Vascular smooth muscle cells (VSMCs) are integral components of vascular structure and …

Application and study of ROCK inhibitors in pulmonary fibrosis: recent developments and future perspectives

Y Xie, L Yue, Y Shi, X Su, C Gan, H Liu… - Journal of Medicinal …, 2023 - ACS Publications
Rho-associated coiled-coil-containing kinases (ROCKs), serine/threonine protein kinases,
were initially identified as downstream targets of the small GTP-binding protein Rho …

Nitroaromatic hypoxia-activated prodrugs for cancer therapy

WA Denny - Pharmaceuticals, 2022 - mdpi.com
The presence of “hypoxic” tissue (with O2 levels of< 0.1 mmHg) in solid tumours, resulting in
quiescent tumour cells distant from blood vessels, but capable of being reactivated by …

Hypoxia-activated prodrug derivatives of anti-cancer drugs: a patent review 2006–2021

E Anduran, LJ Dubois, P Lambin… - Expert opinion on …, 2022 - Taylor & Francis
Introduction The hypoxic tumor microenvironment represents a persistent obstacle in the
treatment of most solid tumors. In the past years, significant efforts have been made to …

NIR-light-intensified hypoxic microenvironment for cascaded supra-prodrug activation and synergistic chemo/photodynamic cancer therapy

H Chen, T Sun, W Zeng, X Zeng, L Mei… - ACS Materials …, 2021 - ACS Publications
Despite the fact that photodynamic therapy (PDT) has promising clinical prospects, its
therapeutic efficacy is still restricted by the hypoxic tumor microenvironment (TME) …

[HTML][HTML] Recent Advances in the Application of Nitro (het) aromatic Compounds for Treating and/or Fluorescent Imaging of Tumor Hypoxia

K Anichina, N Lumov, V Bakov, D Yancheva… - Molecules, 2024 - mdpi.com
This review delves into recent advancements in the field of nitro (het) aromatic bioreductive
agents tailored for hypoxic environments. These compounds are designed to exploit the low …

Fasudil ameliorates methotrexate-induced hepatotoxicity by modulation of redox-sensitive signals

EM Aboubakr, ARN Ibrahim, FEM Ali, AAE Mourad… - Pharmaceuticals, 2022 - mdpi.com
Methotrexate (MTX) is one of the most widely used cytotoxic chemotherapeutic agents, and it
is used in the treatment of different autoimmune disorders. However, the clinical applications …

[HTML][HTML] Non-Muscle Myosin II A: Friend or Foe in Cancer?

W Feroz, BSY Park, M Siripurapu, N Ntim… - International Journal of …, 2024 - mdpi.com
Non-muscle myosin IIA (NM IIA) is a motor protein that belongs to the myosin II family. The
myosin heavy chain 9 (MYH9) gene encodes the heavy chain of NM IIA. NM IIA is a hexamer …