The discovery of microRNAs (miRNAs) 20 years ago has advocated a new era of “small
molecular genetics.” About 2000 miRNAs are present that regulate one third of the genome …

The incidence of type 2 diabetes mellitus (T2DM), the most prevalent metabolic disease, is
rapidly growing worldwide. T2DM has several underlying causes involved in its …

Abstract Background Type 1 diabetes (T1DM) severely threatens human health, and the
dysfunction of insulin-secreting β cells in islets is related to the reduced PDX-1 expression. It …

Long non‐coding RNAs (lncRNAs) are frequently dysregulated and play important roles in
many cancers. lncRNA H19 is one of the earliest discovered lncRNAs which has diverse …

Epilepsy is a life-threatening neurological disease that affects approximately 70 million
people worldwide. Although the vast majority of patients may be successfully managed with …

Objective. Cancer stem-like cells (CSLCs) are closely associated with tumor recurrence,
metastasis, and drug-resistance. PHD-finger domain protein 5A (PHF5A) is related to …

Transplantation of pancreatic islet cells is a promising strategy for the long-term treatment of
type 1 diabetes (T1D). The stem cell-derived beta cells showed great potential as substitute …

In recent years, great breakthroughs have been made in basic research and clinical
applications of stem cells in regenerative medicine and other fields, which continue to …

Generating insulin-producing cells (IPCs) from human pluripotent stem cells is a promising
method for studying the molecular mechanism underlying pancreas development and a …

Abstract Type 1 diabetes (T1D) is an autoimmune disease caused by the interaction
between genetic alterations and environmental factors. More than 60 susceptible genes or …