While oxygen is critical to the continued existence of complex organisms, extreme levels of
oxygen within a system, known as hypoxia (low levels of oxygen) and hyperoxia (excessive …

Herein, we use lessons learned in exercise physiology and metabolism to propose that
augmented lactate production ('lactagenesis'), initiated by gene mutations, is the reason and …

Lactate (La−) has long been at the center of controversy in research, clinical, and athletic
settings. Since its discovery in 1780, La− has often been erroneously viewed as simply a …

The hallmarks of cancer described by Hanahan and Weinberg have proved seminal in our
understanding of cancer's common traits and in rational drug design. Not free of critique and …

Tumor hypoxia is a well-established biological phenomenon that affects the curability of
solid tumors, regardless of treatment modality. Especially for head and neck cancer patients …

If carcinogenesis occurs by somatic evolution, then common components of the cancer
phenotype result from active selection and must, therefore, confer a significant growth …

The functional and therapeutic importance of the Warburg effect is increasingly recognized,
and glycolysis has become a target of anticancer strategies. We recently reported the …

Hypoxia, a characteristic feature of locally advanced solid tumors, has emerged as a pivotal
factor of the tumor (patho-) physiome since it can promote tumor progression and resistance …

18F-FDG PET is often used in clinical routine for diagnosis, staging, and response to therapy
assessment or prediction. The standardized uptake value (SUV) in the primary or regional …

Cancers of diverse origins exhibit marked glucose avidity and high rates of aerobic
glycolysis. Increased understanding of this dysfunctional metabolism known as the Warburg …