Chronic inflammatory arthritis in childhood is heterogeneous in presentation and course.
Most forms exhibit clinical and genetic similarity to arthritis of adult onset, although at least …

Crohn's disease manifests during childhood or adolescence in up to 25% of patients. The
potential for linear growth impairment as a complication of chronic intestinal inflammation is …

Objective To identify the mediator responsible for the impact of chronic inflammation on
skeletal development in children (bone loss, defective peak bone mass accrual, stunted …

Background Cachexia frequently occurs in women with advanced ovarian cancer (OC),
along with enhanced inflammation. Despite being responsible for one third of all cancer …

Adult rheumatoid arthritis (RA), a systemic autoimmune disorder of unknown etiology, is
characterized by dysfunctional cellular and humoral immunity, enhanced migration and …

Children and adolescents with chronic diseases are commonly affected by a variable
degree of growth failure, leading to an impaired final height. Of note, the peculiar onset …

Osteoarthritis (OA), the most common chronic rheumatic disease, is mainly characterized by
a progressive degradation of the hyaline articular cartilage, which is essential for correct …

Histone deacetylase (HDAC) inhibitors are efficacious epigenetic-based therapies for some
cancers and neurological disorders; however, each of these drugs inhibits multiple HDACs …

Longitudinal bone growth is a tightly regulated process that relies on complex synchronized
mechanisms at the growth plate. Chronic paediatric inflammatory diseases are well …

Growth disorders are common among patients with juvenile idiopathic arthritis (JIA). These
disorders range from general growth retardation to local acceleration of growth in the …