Plasmacytoid dendritic cells (pDCs) are a unique DC subset that specializes in the
production of type I interferons (IFNs). pDCs promote antiviral immune responses and have …

Toll-like receptors (TLRs) play crucial roles in the innate immune system by recognizing
pathogen-associated molecular patterns derived from various microbes. TLRs signal …

Plasmacytoid dendritic cells (pDCs) are a unique subset of dendritic cells specialised in
secreting high levels of type I interferons. pDCs play a crucial role in antiviral immunity and …

Plasmacytoid dendritic cells (pDCs) comprise a subset of dendritic cells characterized by
their ability to produce large amount of type I interferon (IFN-I/α). Originally recognized for …

Dock family proteins are evolutionary conserved exchange factors for the Rho GTPases Rac
and Cdc42. There are 11 Dock proteins in mammals, named Dock1 (or Dock180) to Dock11 …

Background Combined immunodeficiencies are marked by inborn errors of T-cell immunity
in which the T cells that are present are quantitatively or functionally deficient. Impaired …

To migrate efficiently through the interstitium, dendritic cells (DCs) constantly adapt their
shape to the given structure of the extracellular matrix and follow the path of least resistance …

DOCK8 mutations result in an inherited combined immunodeficiency characterized by
increased susceptibility to skin and other infections. We show that when DOCK8-deficient T …

CpG oligodeoxynucleotides (CpG ODNs), the artificial versions of unmethylated CpG motifs
that were originally discovered in bacterial DNA, are demonstrated not only as potent …

Dedicator of cytokinesis (DOCK) proteins constitute a family of evolutionarily conserved
guanine nucleotide exchange factors (GEFs) for the Rho family of GTPases. Although DOCK …