In various diseases, there is an increased production of the free radicals needed to carry out
certain physiological processes but their excessive amounts can cause oxidative stress and …

Intrinsically disordered proteins (IDPs) and intrinsically disordered protein regions (IDPRs)
are functional proteins and domains that devoid stable secondary and/or tertiary structure …

The discovery of the nitric oxide/cGMP pathway was the basis for our understanding of many
normal physiological functions and the pathophysiology of several diseases. Since the …

Free radicals, reactive oxygen/nitrogen species (ROS/RNS), hydrogen sulphide, and
hydrogen peroxide play an important role in both intracellular and intercellular signaling; …

Cyclic guanosine monophosphate (cGMP) is a second messenger molecule that transduces
nitric-oxide-and natriuretic-peptide-coupled signalling, stimulating phosphorylation changes …

Aims Recent clinical trials indicate that sodium-glucose cotransporter 2 (SGLT2) inhibitors
improve cardiovascular outcomes in heart failure patients, but the underlying mechanisms …

Endothelial cells are, by number, one of the most abundant cell types in the heart and active
players in cardiac physiology and pathology. Coronary angiogenesis plays a vital role in …

Patients with chronic kidney disease have an increased cardiovascular morbidity and
mortality. It has been recognized that the traditional cardiovascular risk factors could only …

Homeostasis around vascular endothelium is a function of the equilibrium between the
bioavailability of nitric oxide (NO) and oxidizing reactive oxygen species (ROS). Within the …

Significance: Over-nutrition and sedentary lifestyle has led to a worldwide increase in
obesity, insulin resistance, and type 2 diabetes (T2D) associated with an increased risk of …