Increased levels of glucocorticoid hormones—the main product of the hypothalamic‐pituitary‐
adrenal (HPA) axis—have been considered to be “depressogenic,” but this notion has …

AIM: Posttraumatic stress disorder (PTSD), major depressive disorder (MDD), and severe
fatigue may develop in response to severe stress and trauma. These conditions have all …

Icariin is a major constituent of flavonoids isolated from Herba Epimedii. Several previous
studies have demonstrated the antidepressant-like effects of icariin. After oral administration …

Objective: Testosterone may have a role distinct from cortisol in the pathophysiology of
depression. The hypothalamus-pituitary-adrenal (HPA) axis affects the functions of sex …

Directly measuring hypothalamic pituitary adrenal (HPA) axis function, an important player in
affective disorders, is intensive and invasive. A crucial component of this system, the activity …

There is extensive evidence linking inflammation with depression, but the nature of this
relationship remains unclear. This PhD consisted of two studies that aimed to investigate the …

Accumulated evidence points to immunological factors in psychiatric disorders. In a variety
of chronic neurological disorders, exacerbation is associated with inflammation and a loss of …