[HTML][HTML] The role of metabolism in chondrocyte dysfunction and the progression of osteoarthritis
L Zheng, Z Zhang, P Sheng, A Mobasheri - Ageing research reviews, 2021 - Elsevier
Osteoarthritis (OA) is a degenerative joint disease characterized by low-grade inflammation
and high levels of clinical heterogeneity. Aberrant chondrocyte metabolism is a response to …
and high levels of clinical heterogeneity. Aberrant chondrocyte metabolism is a response to …
[HTML][HTML] Mitochondrial Sirtuin 3: New emerging biological function and therapeutic target
J Zhang, H Xiang, J Liu, Y Chen, RR He, B Liu - Theranostics, 2020 - ncbi.nlm.nih.gov
Abstract Sirtuin 3 (SIRT3) is one of the most prominent deacetylases that can regulate
acetylation levels in mitochondria, which are essential for eukaryotic life and inextricably …
acetylation levels in mitochondria, which are essential for eukaryotic life and inextricably …
The ambiguous role of sirtuins in head and neck squamous cell carcinoma
D Ezhilarasan, T Lakshmi, M Subha… - Oral …, 2022 - Wiley Online Library
Oral cancer is one of the most leading cancer responsible for significant morbidity and
mortality. The sirtuins (SIRTs) are a family of class III histone deacetylases and are known to …
mortality. The sirtuins (SIRTs) are a family of class III histone deacetylases and are known to …
The role of sirtuins in antioxidant and redox signaling
Significance: Antioxidant and redox signaling (ARS) events are regulated by critical
molecules that modulate antioxidants, reactive oxygen species (ROS) or reactive nitrogen …
molecules that modulate antioxidants, reactive oxygen species (ROS) or reactive nitrogen …
Protein posttranslational modifications in health and diseases: Functions, regulatory mechanisms, and therapeutic implications
Q Zhong, X Xiao, Y Qiu, Z Xu, C Chen, B Chong… - MedComm, 2023 - Wiley Online Library
Protein posttranslational modifications (PTMs) refer to the breaking or generation of covalent
bonds on the backbones or amino acid side chains of proteins and expand the diversity of …
bonds on the backbones or amino acid side chains of proteins and expand the diversity of …
Sirtuin 3 protects against anesthesia/surgery-induced cognitive decline in aged mice by suppressing hippocampal neuroinflammation
Q Liu, YM Sun, H Huang, C Chen, J Wan… - Journal of …, 2021 - Springer
Background Postoperative cognitive dysfunction (POCD) is a very common complication that
might increase the morbidity and mortality of elderly patients after surgery. However, the …
might increase the morbidity and mortality of elderly patients after surgery. However, the …
SIRT3‐dependent delactylation of cyclin E2 prevents hepatocellular carcinoma growth
J Jin, L Bai, D Wang, W Ding, Z Cao, P Yan, Y Li… - EMBO …, 2023 - embopress.org
Lysine lactylation (Kla) is a recently discovered histone mark derived from metabolic lactate.
The NAD+‐dependent deacetylase SIRT3, which can also catalyze removal of the lactyl …
The NAD+‐dependent deacetylase SIRT3, which can also catalyze removal of the lactyl …
Role of nicotinamide adenine dinucleotide and related precursors as therapeutic targets for age-related degenerative diseases: rationale, biochemistry …
Significance: Nicotinamide adenine dinucleotide (NAD+) is an essential pyridine nucleotide
that serves as an essential cofactor and substrate for a number of critical cellular processes …
that serves as an essential cofactor and substrate for a number of critical cellular processes …
The path from mitochondrial ROS to aging runs through the mitochondrial permeability transition pore
H Rottenberg, JB Hoek - Aging cell, 2017 - Wiley Online Library
Excessive production of mitochondrial reactive oxygen species (mROS) is strongly
associated with mitochondrial and cellular oxidative damage, aging, and degenerative …
associated with mitochondrial and cellular oxidative damage, aging, and degenerative …