1962). Indeed, the two membranes are separated by a Calcium plays an important role in
regulating a great fuzzy material with a distinct periodicity reminiscent of variety of neuronal …

The Na+/Ca2+ exchanger, an ion transport protein, is expressed in the plasma membrane
(PM) of virtually all animal cells. It extrudes Ca2+ in parallel with the PM ATP-driven Ca2+ …

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The inositol 1, 4, 5-trisphosphate (InsP3) receptors (InsP3Rs) are a family of Ca2+ release
channels localized predominately in the endoplasmic reticulum of all cell types. They …

The cloning of a G protein-coupled extracellular Ca2+ (Cao 2+)-sensing receptor (CaR) has
elucidated the molecular basis for many of the previously recognized effects of Cao 2+ on …

Studies on control of fluid secretion by an insect salivary gland led to the discovery of inositol
trisphosphate (IP3) and its role in calcium signalling. Many cell stimuli act on receptors that …

The physiological effects of glucagon-like peptide-1 (GLP-1) are of immense interest
because of the potential clinical relevance of this peptide. Produced in intestinal L-cells …

The calcium ion (Ca2+) is the simplest and most versatile intracellular messenger known.
The discovery of Ca2+ sparks and a related family of elementary Ca2+ signaling events has …

Calcium is a ubiquitous second messenger used to regulate a wide range of cellular
processes. This role in signalling has to be conducted against the rigid homeostatic …

Calcium (Ca2+) is an almost universal intracellular messenger, controlling a diverse range
of cellular processes, such as gene transcription (see Mellström and Naranjo, this issue) …