The SARS-CoV-2 spike glycoprotein biosynthesis, structure, function, and antigenicity: implications for the design of spike-based vaccine immunogens
L Duan, Q Zheng, H Zhang, Y Niu, Y Lou… - Frontiers in …, 2020 - frontiersin.org
The ongoing pandemic of coronavirus disease 2019 (COVID-19), caused by severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2), poses a grave threat to global public …
respiratory syndrome coronavirus 2 (SARS-CoV-2), poses a grave threat to global public …
Molecular mechanism of HIV-1 entry
B Chen - Trends in microbiology, 2019 - cell.com
HIV-1 envelope glycoprotein [Env; trimeric (gp160) 3 cleaved to (gp120/gp41) 3] attaches
the virion to a susceptible cell and induces fusion of viral and cell membranes to initiate …
the virion to a susceptible cell and induces fusion of viral and cell membranes to initiate …
[HTML][HTML] Molecular basis of receptor binding and antibody neutralization of Omicron
Q Hong, W Han, J Li, S Xu, Y Wang, C Xu, Z Li, Y Wang… - Nature, 2022 - nature.com
Abstract The SARS-CoV-2 Omicron variant exhibits striking immune evasion and is
spreading rapidly worldwide. Understanding the structural basis of the high transmissibility …
spreading rapidly worldwide. Understanding the structural basis of the high transmissibility …
Conformational dynamics of SARS-CoV-2 trimeric spike glycoprotein in complex with receptor ACE2 revealed by cryo-EM
The recent outbreaks of SARS-CoV-2 pose a global health emergency. The SARS-CoV-2
trimeric spike (S) glycoprotein interacts with the human ACE2 receptor to mediate viral entry …
trimeric spike (S) glycoprotein interacts with the human ACE2 receptor to mediate viral entry …
Immunogenicity and structures of a rationally designed prefusion MERS-CoV spike antigen
Middle East respiratory syndrome coronavirus (MERS-CoV) is a lineage C betacoronavirus
that since its emergence in 2012 has caused outbreaks in human populations with case …
that since its emergence in 2012 has caused outbreaks in human populations with case …
Live imaging of SARS-CoV-2 infection in mice reveals that neutralizing antibodies require Fc function for optimal efficacy
Neutralizing antibodies (NAbs) are effective in treating COVID-19, but the mechanism of
immune protection is not fully understood. Here, we applied live bioluminescence imaging …
immune protection is not fully understood. Here, we applied live bioluminescence imaging …
[HTML][HTML] Real-time conformational dynamics of SARS-CoV-2 spikes on virus particles
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike (S) mediates
viral entry into cells and is critical for vaccine development against coronavirus disease …
viral entry into cells and is critical for vaccine development against coronavirus disease …
Structural basis and mode of action for two broadly neutralizing antibodies against SARS-CoV-2 emerging variants of concern
Emerging variants of concern for the severe acute respiratory syndrome coronavirus 2
(SARS-CoV-2) can transmit more efficiently and partially evade protective immune …
(SARS-CoV-2) can transmit more efficiently and partially evade protective immune …
Structure and immune recognition of trimeric pre-fusion HIV-1 Env
The human immunodeficiency virus type 1 (HIV-1) envelope (Env) spike, comprising three
gp120 and three gp41 subunits, is a conformational machine that facilitates HIV-1 entry by …
gp120 and three gp41 subunits, is a conformational machine that facilitates HIV-1 entry by …
Broadly neutralizing antibodies to HIV and their role in vaccine design
DR Burton, L Hangartner - Annual review of immunology, 2016 - annualreviews.org
HIV employs multiple means to evade the humoral immune response, particularly the
elicitation of and recognition by broadly neutralizing antibodies (bnAbs). Such antibodies …
elicitation of and recognition by broadly neutralizing antibodies (bnAbs). Such antibodies …