Breast cancer is an increasing public health problem. Substantial advances have been
made in the treatment of breast cancer, but the introduction of methods to predict women at …

Breast cancer prevention is daunting, yet not an unsurmountable goal. Mammary stem and
progenitors have been proposed as the cells‐of‐origin in breast cancer. Here, we present …

Several studies have made strong efforts to understand how age and parity modulate the
risk of breast cancer. A holistic understanding of the dynamic regulation of the …

Abstract Purpose: Cyclin-dependent kinase 4/6 (CDK4/6) inhibitors are currently used in
combination with endocrine therapy to treat advanced hormone receptor–positive, HER2 …

Background In breast cancer, complex interactions between tumor cells and cells within the
surrounding stroma, such as macrophages, are critical for tumor growth, progression, and …

Significant endocrine therapy–resistant tumor proliferation is present in≥ 20% of estrogen
receptor–positive (ER+) primary breast cancers and is associated with disease recurrence …

Janus kinases (JAKs) and signal transducers and activators of transcription (STATs) have
been shown to function downstream of several peptide hormones and cytokines that are …

Background Psychiatric medications are widely prescribed in the USA. Many antipsychotics
cause serum hyperprolactinemia as an adverse side effect; prolactin-Janus kinase 2 (JAK2) …

The accumulation of somatic mutations in healthy human tissues has been extensively
characterized, but the mutational landscape of the healthy breast is still poorly understood …

Through the concerted efforts of many patients, health-care providers, legislators, and other
supporters, the past decade has seen the development of the first clinics dedicated to the …