[HTML][HTML] FoxP3+ T regulatory cells in cancer: Prognostic biomarkers and therapeutic targets
T Regulatory cells (Tregs) can have both protective and pathological roles. They maintain
immune homeostasis and inhibit immune responses in various diseases, including cancer …
immune homeostasis and inhibit immune responses in various diseases, including cancer …
Treg-mediated acquired resistance to immune checkpoint inhibitors
T Regulatory cells (Tregs) act as a double-edged sword by regulating immune homeostasis
(protective role) and inhibiting immune responses in different disease settings (pathological …
(protective role) and inhibiting immune responses in different disease settings (pathological …
Treg cell-derived osteopontin promotes microglia-mediated white matter repair after ischemic stroke
L Shi, Z Sun, W Su, F Xu, D Xie, Q Zhang, X Dai, K Iyer… - Immunity, 2021 - cell.com
The precise mechanisms underlying the beneficial effects of regulatory T (Treg) cells on long-
term tissue repair remain elusive. Here, using single-cell RNA sequencing and flow …
term tissue repair remain elusive. Here, using single-cell RNA sequencing and flow …
PD-L1–PD-1 interactions limit effector regulatory T cell populations at homeostasis and during infection
Phenotypic and transcriptional profiling of regulatory T (Treg) cells at homeostasis reveals
that T cell receptor activation promotes Treg cells with an effector phenotype (eTreg) …
that T cell receptor activation promotes Treg cells with an effector phenotype (eTreg) …
[HTML][HTML] Notch4 signaling limits regulatory T-cell-mediated tissue repair and promotes severe lung inflammation in viral infections
A cardinal feature of COVID-19 is lung inflammation and respiratory failure. In a prospective
multi-country cohort of COVID-19 patients, we found that increased Notch4 expression on …
multi-country cohort of COVID-19 patients, we found that increased Notch4 expression on …
Three types of functional regulatory T cells control T cell responses at the human maternal-fetal interface
M Salvany-Celades, A van der Zwan, M Benner… - Cell reports, 2019 - cell.com
During pregnancy, maternal regulatory T cells (Tregs) are important in establishing immune
tolerance to invading fetal extravillous trophoblasts (EVTs). CD25 HI FOXP3+ Tregs are …
tolerance to invading fetal extravillous trophoblasts (EVTs). CD25 HI FOXP3+ Tregs are …
Single cell transcriptomic analysis of the immune cell compartment in the human small intestine and in Celiac disease
Celiac disease is an autoimmune disorder in which ingestion of dietary gluten triggers an
immune reaction in the small intestine leading to destruction of the lining epithelium. Current …
immune reaction in the small intestine leading to destruction of the lining epithelium. Current …
Functional effects of chimeric antigen receptor co-receptor signaling domains in human regulatory T cells
NAJ Dawson, I Rosado-Sánchez… - Science Translational …, 2020 - science.org
Antigen-specific regulatory T cells (Tregs) engineered with chimeric antigen receptors
(CARs) are a potent immunosuppressive cellular therapy in multiple disease models and …
(CARs) are a potent immunosuppressive cellular therapy in multiple disease models and …
Loss-of-function mutation in IKZF2 leads to immunodeficiency with dysregulated germinal center reactions and reduction of MAIT cells
I Hetemäki, M Kaustio, M Kinnunen, N Heikkilä… - Science …, 2021 - science.org
The Ikaros family transcription factors regulate lymphocyte development. Loss-of-function
variants in IKZF1 cause primary immunodeficiency, but Ikaros family members IKZF2 and …
variants in IKZF1 cause primary immunodeficiency, but Ikaros family members IKZF2 and …
Repertoire analyses reveal T cell antigen receptor sequence features that influence T cell fate
T cells acquire a regulatory phenotype when their T cell antigen receptors (TCRs)
experience an intermediate-to high-affinity interaction with a self-peptide presented via the …
experience an intermediate-to high-affinity interaction with a self-peptide presented via the …