Epidermolysis bullosa (EB) is a heterogeneous group of rare inherited blistering skin
disorders characterized by skin fragility following minor trauma, usually present since birth …

The term 'keratin'is generally accepted to refer to the epithelial keratins of soft and hard
epithelial tissues such as: skin, cornea, hair and nail. Since their initial characterization, the …

CRISPR/Cas9-based therapeutics hold the possibility for permanent treatment of genetic
disease. The potency and specificity of this system has been used to target dominantly …

CRISPR/Cas9 holds immense potential to treat a range of genetic disorders. Allele-specific
gene disruption induced by non-homologous end-joining (NHEJ) DNA repair offers a …

Keratins are cytoskeletal filament-forming proteins found in skin and other epithelial (sheet)
tissues (Table 1). Keratins (type I and II), and other highly related (types III–VI) intermediate …

Epidermolysis bullosa simplex (EBS) is a rare genetic condition typified by superficial
bullous lesions following incident frictional trauma to the skin. Most cases of EBS are due to …

The major unmet need and crucial challenge hampering the exciting potential of RNAi
therapeutics in ophthalmology is to find an effective, safe and non-invasive means of …

Nucleic acids (NAs) hold significant potential for the treatment of several diseases. Topical
delivery of NAs for the treatment of skin diseases is especially advantageous since it …

Genetic skin fragility manifests with diminished resistance of the skin and mucous
membranes to external mechanical forces and with skin blistering, erosions, and painful …

The epidermis is a stratified epithelium that relies on its cytoskeleton and cell junctions to
protect the body against mechanical injury, dehydration, and infections. Keratin intermediate …