Therapeutic antitumor antibodies treat cancer by mobilizing both innate and adaptive
immunity. CD47 is an antiphagocytic ligand exploited by tumor cells to blunt antibody …

B cells are activated by two temporally distinct signals, the first provided by the binding of
antigen to the B cell antigen receptor (BCR), and the second provided by helper T cells …

One common way to study human leucocytes and cancer cells in an experimental in vivo
situation is to use mice that have been genetically engineered to lack an immune system …

Key events in T cell–dependent antibody responses, including affinity maturation, are
dependent on the B cell's presentation of antigen to helper T cells at critical checkpoints in …

There are over 400 ongoing clinical trials using tumor-derived vaccines. This approach is
especially attractive for many types of brain tumors, including glioblastoma, yet so far the …

Distinct neutrophil populations arise during certain pathological conditions. The generation
of dysfunctional neutrophils during sepsis and their contribution to septicemia-related …

Rationale: Inflammation is a basic component of the pathogenesis of atherosclerosis.
CD200 is an immune checkpoint known to control macrophage activation. CD200 recently …

The interaction between CD200 and its receptor CD200R1 is among the central regulators
of microglia and macrophage phenotype. However, it remains to be established whether, in …

Constant exposure to foreign particles in the airways requires tight immune regulation in
order to maintain sufficient anti-microbial defences, while preventing immunopathological …

Barcoding of biological samples is a commonly used strategy to mark or identify individuals
within a complex mixture. However, cell barcoding has not yet found wide use in flow …