A reference cell tree will serve science better than a reference cell atlas
S Domcke, J Shendure - Cell, 2023 - cell.com
Single-cell biology is facing a crisis of sorts. Vast numbers of single-cell molecular profiles
are being generated, clustered and annotated. However, this is overwhelmingly ad hoc, and …
are being generated, clustered and annotated. However, this is overwhelmingly ad hoc, and …
Spatial and temporal organization of the genome: Current state and future aims of the 4D nucleome project
The four-dimensional nucleome (4DN) consortium studies the architecture of the genome
and the nucleus in space and time. We summarize progress by the consortium and highlight …
and the nucleus in space and time. We summarize progress by the consortium and highlight …
A time-resolved, multi-symbol molecular recorder via sequential genome editing
DNA is naturally well suited to serve as a digital medium for in vivo molecular recording.
However, contemporary DNA-based memory devices are constrained in terms of the …
However, contemporary DNA-based memory devices are constrained in terms of the …
[PDF][PDF] Clonally heritable gene expression imparts a layer of diversity within cell types
Cell types can be classified according to shared patterns of transcription. Non-genetic
variability among individual cells of the same type has been ascribed to stochastic …
variability among individual cells of the same type has been ascribed to stochastic …
Defining ancestry, heritability and plasticity of cellular phenotypes in somatic evolution
The broad application of single-cell RNA sequencing has revealed transcriptional cell state
heterogeneity across diverse healthy and malignant somatic tissues. Recent advances in …
heterogeneity across diverse healthy and malignant somatic tissues. Recent advances in …