Impairment of insulin action and metabolic dysregulation have traditionally been associated
with schizophrenia, although the molecular basis of such association remains still elusive …

Background: d-Serine, a direct, full agonist at the d-serine/glycine modulatory site of the N-
methyl-D-aspartate-type glutamate receptors (NMDAR), has been assessed as a treatment …

D-Amino acids, the enantiomers of L-amino acids, are increasingly recognized as novel
biomarkers. Although the amounts of D-amino acids are usually very trace in human, some …

Hyperglycemia is a representative hallmark and risk factor for diabetes mellitus (DM) and is
closely linked to DM‐associated neuronal cell death. Previous investigators reported on a …

It is widely accepted that some of the free d-amino acids play important biological role. d-
Aspartate and d-serine formed in the central nervous system of higher vertebrates have …

d-Serine is an essential coagonist with glutamate for stimulation of N-methyl-d-aspartate
(NMDA) glutamate receptors. Although astrocytic metabolic processes are known to regulate …

Behavioral disorders affect most diabetic patients and Zinc (Zn) has been used among
adjuvant therapies for involvement in the etiology of depression and anxiety, however, the …

Diabetes-associated cognitive dysfunction (DACD) has ascended to become the second
leading cause of mortality among diabetic patients. Phosphoserine phosphatase (PSPH), a …

The animal model of streptozotocin‐induced diabetes mellitus type 1 (DM1) is used to study
neuronal and behavioral changes produced by an increase in blood‐glucose levels. Our …

Background and aims Alteration in the insulin signaling could contribute to the development
of Alzheimer's disease (AD) through metabolic or inflammatory processes, adipokines could …