As the median age of the population increases, the number of individuals with Alzheimer's
disease (AD) and the associated socio-economic burden are predicted to worsen. While …

Essential metals are crucial for the maintenance of cell homeostasis. Among the 23
elements that have known physiological functions in humans, 12 are metals, including iron …

Background Beta-amyloid (Abeta) and tau protein in cerebrospinal fluid (CSF) are
established diagnostic biomarkers for Alzheimer's disease (AD). However, these biomarkers …

This article brings the choroid plexus into the context of health and disease. It is remarkable
that the choroid plexus, composed by a monolayer of epithelial cells that lie in a highly …

Background: On target 18F-Flortaucipir (FTP) binding of Alzheimer's disease tau aggregates
and off-target binding of melanocytes have been demonstrated with autoradiography …

Choroid plexus epithelial cells can secrete cerebrospinal fluid into the ventricles, serving as
the major structural basis of the selective barrier between the neurological system and blood …

The choroid plexus is a complex structure which hangs inside the ventricles of the brain and
consists mainly of choroid plexus epithelial (CPE) cells surrounding fenestrated capillaries …

The production, accumulation and aggregation of amyloid beta (Aβ) peptides in Alzheimer's
disease (AD) are influenced by different modulators. Among these are iron and iron-related …

Background Alzheimer's disease (AD) is the most common form of dementia. AD has a
multifactorial disease etiology and is currently untreatable. Multiple genes and molecular …

Aceruloplasminemia is a monogenic disease caused by mutations in the ceruloplasmin
gene that result in loss of protein ferroxidase activity. Ceruloplasmin plays a role in iron …