Objectives We aimed to conduct a systematic review and meta-analysis on the incidence
and prevalence of SSc covering the entire literature. Methods This study followed the …

From the clinical standpoint, systemic sclerosis (SSc) is characterized by skin and internal
organ fibrosis, diffuse fibroproliferative vascular modifications, and autoimmunity. Clinical …

Systemic sclerosis (SSc), also referred to as systemic scleroderma or scleroderma, is a rare,
complex immune-mediated connective tissue disease characterized by progressive skin …

Systemic lupus erythematosus, systemic sclerosis, rheumatoid arthritis, and Sjögren's
syndrome are four major autoimmune rheumatic diseases characterized by the presence of …

Systemic sclerosis is a rare and chronic connective tissue disease with a multifaceted
pathogenesis characterised by heterogeneous multi-organ clinical manifestations. Every …

Systemic sclerosis (SSc) is a connective tissue disease characterized by extensive fibrosis
of the skin and internal organs, associated with vasculopathy and autoimmune features …

Gene expression signatures can stratify patients with heterogeneous diseases, such as
systemic lupus erythematosus (SLE), yet understanding the contributions of ancestral …

Understanding the epidemiological factors in SSc enables patient care through patient
classification, prognostication, and monitoring. Future research may emphasize enrichment …

In genomic medicine, the concept of genetically transitional disease (GTD) refers to cases in
which gene mutation is necessary but not sufficient to cause disease. In this Perspective, we …

Systemic sclerosis (SSc) is an autoimmune disease characterized by abnormalities in
microcirculation, extracellular matrix accumulation, and immune activation. Autoantibodies …