The immune system is a very diverse system of the host that evolved during evolution to
cope with various pathogens present in the vicinity of environmental surroundings inhabited …

In the year 2000, cytomegalovirus was identified as a risk factor for mortality in a seminal
study of octogenarian residents in Sweden. This finding triggered a wave of additional …

Toll-like receptors (TLRs) are pathogen recognition receptors, and primitive sources of
innate immune response that also play key roles in the defense mechanism against …

Ovarian cancer (OC) is one of the most common cancers threatening women's lives around
the world. Epithelial ovarian tumors represent the most common ovarian neoplasms. Most …

Abstract Toll-like receptor 3 (TLR3), an endosomal receptor crucial for immune responses
upon viral invasion. The TLR3 ectodomain (ECD) is responsible for double-stranded RNA …

Congenital Zika syndrome (CZS) is a cluster of malformation, and the mechanisms that lead
it are still unclear. Using hypothesis-driven candidate genes and their function in viral …

The identification of high-risk factors for the infection by SARS-CoV-2 and the negative
outcome of COVID-19 is crucial. The genetic background of the host might account for …

Genetic determinants of BK polyomavirus infection after kidney transplantation remain
poorly investigated. We assessed the potential impact of 13 different single nucleotide …

Several genetic polymorphisms of the innate immune system have been described to
increase the risk of cytomegalovirus (CMV) infection in transplant patients. The aim of this …

Abstract Toll-like receptor 3 (TLR3) is a pattern recognition receptor mainly known for its role
in innate immune response to infection. Indeed, binding of double-stranded RNA (dsRNA) to …