Antimicrobial peptides: diversity, mechanism of action and strategies to improve the activity and biocompatibility in vivo

P Kumar, JN Kizhakkedathu, SK Straus - Biomolecules, 2018 - mdpi.com
Antibiotic resistance is projected as one of the greatest threats to human health in the future
and hence alternatives are being explored to combat resistance. Antimicrobial peptides …

[HTML][HTML] Reassessing the host defense peptide landscape

EF Haney, SK Straus, REW Hancock - Frontiers in chemistry, 2019 - frontiersin.org
Current research has demonstrated that small cationic amphipathic peptides have strong
potential not only as antimicrobials, but also as antibiofilm agents, immune modulators, and …

Antimicrobial peptides: interaction with model and biological membranes and synergism with chemical antibiotics

A Hollmann, M Martinez, P Maturana… - Frontiers in …, 2018 - frontiersin.org
Antimicrobial peptides (AMPs) are promising novel antibiotics since they have shown
antimicrobial activity against a wide range of bacterial species, including multiresistant …

Host defense peptides: front-line immunomodulators

SC Mansour, OM Pena, REW Hancock - Trends in immunology, 2014 - cell.com
Although first studied for their antimicrobial activity, host defense peptides (HDPs) are now
widely recognized for their multifunctional roles in both the innate and adaptive immune …

Contribution of amphipathicity and hydrophobicity to the antimicrobial activity and cytotoxicity of β-hairpin peptides

IA Edwards, AG Elliott, AM Kavanagh… - ACS infectious …, 2016 - ACS Publications
Bacteria have acquired extensive resistance mechanisms to protect themselves against
antibiotic action. Today the bacterial membrane has become one of the “final frontiers” in the …

Engineered polymer nanoparticles with unprecedented antimicrobial efficacy and therapeutic indices against multidrug-resistant bacteria and biofilms

A Gupta, RF Landis, CH Li, M Schnurr… - Journal of the …, 2018 - ACS Publications
The rapid emergence of antibiotic-resistant bacterial “superbugs” with concomitant treatment
failure and high mortality rates presents a severe threat to global health. The superbug risk …

Antimicrobial activity, improved cell selectivity and mode of action of short PMAP-36-derived peptides against bacteria and Candida

Y Lyu, Y Yang, X Lyu, N Dong, A Shan - Scientific reports, 2016 - nature.com
Antimicrobial peptides (AMPs) have recently attracted a great deal of attention as promising
antibiotic candidates, but some obstacles such as toxicity and high synthesis cost must be …

Peptide-functionalized amino acid-derived pseudoprotein-based hydrogel with hemorrhage control and antibacterial activity for wound healing

J Zhu, H Han, F Li, X Wang, J Yu, X Qin… - Chemistry of …, 2019 - ACS Publications
Developing permanent antibacterial and rapid hemostatic wound dressings with excellent
biocompatibility is urgently needed and has always gained great attention. Here, a series of …

Peptides and peptidomimetics for antimicrobial drug design

B Mojsoska, H Jenssen - Pharmaceuticals, 2015 - mdpi.com
The purpose of this paper is to introduce and highlight a few classes of traditional
antimicrobial peptides with a focus on structure-activity relationship studies. After first …

Hydrophobicity determines the bacterial killing rate of α-helical antimicrobial peptides and influences the bacterial resistance development

M Zhang, J Ouyang, L Fu, C Xu, Y Ge… - Journal of medicinal …, 2022 - ACS Publications
Rapid antimicrobial action is an important advantage of antimicrobial peptides (AMPs) over
antibiotics, which is also a reason for AMPs being less likely to induce bacterial resistance …