Studying non-covalent drug–DNA interactions
Drug–DNA interactions have been extensively studied in the recent past. Various
techniques have been employed to decipher these interactions. DNA is a major target for a …
techniques have been employed to decipher these interactions. DNA is a major target for a …
From structure to function: Route to understanding lncRNA mechanism
J Graf, M Kretz - BioEssays, 2020 - Wiley Online Library
RNAs have emerged as a major target for diagnostics and therapeutics approaches.
Regulatory nonprotein‐coding RNAs (ncRNAs) in particular display remarkable versatility …
Regulatory nonprotein‐coding RNAs (ncRNAs) in particular display remarkable versatility …
Conserved pseudoknots in lncRNA MEG3 are essential for stimulation of the p53 pathway
T Uroda, E Anastasakou, A Rossi, JM Teulon… - Molecular cell, 2019 - cell.com
Long non-coding RNAs (lncRNAs) are key regulatory molecules, but unlike with other RNAs,
the direct link between their tertiary structure motifs and their function has proven elusive …
the direct link between their tertiary structure motifs and their function has proven elusive …
A reversibly gated protein-transporting membrane channel made of DNA
Controlled transport of biomolecules across lipid bilayer membranes is of profound
significance in biological processes. In cells, cargo exchange is mediated by dedicated …
significance in biological processes. In cells, cargo exchange is mediated by dedicated …
Systemic delivery of anti-miRNA for suppression of triple negative breast cancer utilizing RNA nanotechnology
D Shu, H Li, Y Shu, G Xiong, WE Carson III, F Haque… - ACS …, 2015 - ACS Publications
MicroRNAs play important roles in regulating the gene expression and life cycle of cancer
cells. In particular, miR-21, an oncogenic miRNA is a major player involved in tumor …
cells. In particular, miR-21, an oncogenic miRNA is a major player involved in tumor …
Guide to video recording of structure dynamics and dynamic processes of proteins by high-speed atomic force microscopy
High-speed atomic force microscopy (HS-AFM) allows direct visualization of dynamic
structural changes and processes of functioning biological molecules in physiological …
structural changes and processes of functioning biological molecules in physiological …
[HTML][HTML] Allele-specific reprogramming of cancer metabolism by the long non-coding RNA CCAT2
Altered energy metabolism is a cancer hallmark as malignant cells tailor their metabolic
pathways to meet their energy requirements. Glucose and glutamine are the major nutrients …
pathways to meet their energy requirements. Glucose and glutamine are the major nutrients …
Design and development of nanosized DNA assemblies in polypod-like structures as efficient vehicles for immunostimulatory CpG motifs to immune cells
K Mohri, M Nishikawa, N Takahashi, T Shiomi… - ACS …, 2012 - ACS Publications
The immunostimulatory activity of phosphodiester DNA containing unmethylated cytosine-
phosphate-guanine (CpG) dinucleotides, or CpG motifs, was significantly increased by the …
phosphate-guanine (CpG) dinucleotides, or CpG motifs, was significantly increased by the …
The molecular structure of long non-coding RNAs: emerging patterns and functional implications
Long non-coding RNAs (lncRNAs) are recently-discovered transcripts that regulate vital
cellular processes and are crucially connected to diseases. Despite their unprecedented …
cellular processes and are crucially connected to diseases. Despite their unprecedented …
Astrocyte EV-induced lincRNA-Cox2 regulates microglial phagocytosis: implications for morphine-mediated neurodegeneration
Impairment of microglial functions, such as phagocytosis and/or dysregulation of immune
responses, has been implicated as an underlying factor involved in the pathogenesis of …
responses, has been implicated as an underlying factor involved in the pathogenesis of …