Chronic asthma is an inflammatory airways disease characterized by pathological changes
in the airway smooth muscle (ASM) bundle that contribute to airway obstruction and …

The biological responses of airway smooth muscle (ASM) are diverse, in part due to ASM
phenotype plasticity. ASM phenotype plasticity refers to the ability of ASM cells to change the …

Asthma is considered a Th2 cell–associated disorder. Despite this, both the Th1 cell–
associated cytokine IFN-γ and airway neutrophilia have been implicated in severe asthma …

Defining mechanisms by which differentiated, contractile smooth muscle cells become
proliferative and secretory in response to mechanical and environmental stress is crucial for …

Rational: Vascular smooth muscle cells (VSMCs) switching from a contractile/differentiated
to a synthetic/dedifferentiated phenotype has an essential role in atherosclerosis …

Airway smooth muscle (ASM) plays a key role in the development of airway
hyperresponsiveness and remodeling in asthma, which may involve maturation of ASM cells …

The development of atherosclerosis involves phenotypic changes among vascular smooth
muscle cells (VSMCs) that correlate with stiffening and remodeling of the extracellular matrix …

Obesity and the metabolic disease epidemic has led to an increase in morbidity and
mortality. A rise in adipose thermogenic capacity via activation of brown or beige fat is a …

Integrins are a large family of transmembrane heterodimeric proteins that constitute the main
receptors for extracellular matrix components. Integrins were initially thought to be primarily …

Clinical asthma is characterized by reversible airway obstruction which is commonly due to
an exaggerated airway narrowing referred to as airway hyperresponsiveness (AHR) …