Assembly-line polyketide synthases (PKSs) are among the most complex protein
machineries known in nature, responsible for the biosynthesis of numerous compounds …

Metabolism is a highly interconnected web of chemical reactions that power life. Though the
stoichiometry of metabolism is well understood, the multidimensional aspects of metabolic …

Understanding the molecular determinants of specificity in protein–protein interaction is an
outstanding challenge of postgenome biology. The availability of large protein databases …

Covering: up to 2015 Multienzyme polyketide synthases (PKSs) are molecular-scale
assembly lines which construct complex natural products in bacteria. The underlying …

Engineered metabolic pathways in microbial cell factories often have no natural
organization and have challenging flux imbalances, leading to low biocatalytic efficiency …

Polyketide synthases (PKSs) catalyze biosynthesis of a diverse family of pharmaceutically
important secondary metabolites. Bioinformatics analysis of sequence and structural …

Bacterial secondary metabolites are an important source of antimicrobial and cytostatic
drugs. These molecules are often synthesized in a stepwise fashion by multimodular …

Accurate and large‐scale prediction of protein–protein interactions directly from amino‐acid
sequences is one of the great challenges in computational biology. Here we present a new …

Nature is providing a bountiful pool of valuable secondary metabolites, many of which
possess therapeutic properties. However, the discovery of new bioactive secondary …

Modular type I polyketide synthases (PKSs) are versatile biosynthetic systems that initiate,
successively elongate, and modify acyl chains. Intermediate transfer between modules is …