X-ray crystal structures are available for 29 eukaryotic microsomal, chloroplast, or
mitochondrial cytochrome P450s, including two non-monooxygenase P450s. These …

This article features selected findings from the senior author and colleagues dating back to
1978 and covering approximately three-fourths of the 60 years since the discovery of …

Microsomal cytochrome b 5 (cytb 5) is a membrane-bound protein that modulates the
catalytic activity of its redox partner, cytochrome P4502B4 (cytP450). Here, we report the first …

Human cytochrome P450 2D6 contributes to the metabolism of> 15% of drugs used in
clinical practice. This study determined the structure of P450 2D6 complexed with a …

Numerous cytochrome P450 (CYP) 2B6 substrates including drugs and environmental
chemicals are halogenated. To assess the role of halogen− π bonds in substrate selectivity …

Drugs that inhibit cytochrome P450 (P450) enzymes through mechanism-based inactivation
(MBI) can significantly affect metabolic interactions, often leading to adverse effects. Despite …

Functional manipulation of biosynthetic enzymes such as cytochrome P450s (or P450s) has
attracted great interest in metabolic engineering of plant natural products. Cucurbitacins and …

The flexibility, active site volume, solvation, and access path dynamics of six metabolically
active mammalian cytochromes P450 (human 2A6, 2C9, 2D6, 2E1, 3A4 and rabbit 2B4) are …

The endoplasmic reticulum (ER)-anchored hepatic cytochromes P450 (P450s) are enzymes
that metabolize endo-and xenobiotics ie drugs, carcinogens, toxins, natural and chemical …

Cytochrome P450 2B6 (CYP2B6) is a highly polymorphic human enzyme involved in the
metabolism of many clinically relevant drugs, environmental toxins, and endogenous …