Nitroaromatic compounds: Environmental toxicity, carcinogenicity, mutagenicity, therapy and mechanism

P Kovacic, R Somanathan - Journal of Applied Toxicology, 2014 - Wiley Online Library
Vehicle pollution is an increasing problem in the industrial world. Aromatic nitro compounds
comprise a significant portion of the threat. In this review, the class includes nitro derivatives …

Prodrug strategies in cancer therapy

WA Denny - European journal of medicinal chemistry, 2001 - Elsevier
Systemic cytotoxic (anti-proliferative) anticancer drugs rely primarily for their therapeutic
effect on cytokinetic differences between cancer and normal cells. One approach aimed at …

Acridine and acridone derivatives, anticancer properties and synthetic methods: where are we now?

P Belmont, J Bosson, T Godet… - Anti-Cancer Agents in …, 2007 - ingentaconnect.com
Acridine derivatives are interesting chemotherapeutic agents that were first used as
antibacterial and antiparasite agents. In this review we wish to concentrate our attention on …

Acridine/acridone: a simple scaffold with a wide range of application in oncology

P Belmont, I Dorange - Expert Opinion on Therapeutic Patents, 2008 - Taylor & Francis
Background: The acridine scaffold is of interest since its DNA affinity and intercalative
properties make it an important pharmacophore for the design of antitumor drugs targeting …

Design, synthesis and high antitumor potential of new unsymmetrical bisacridine derivatives towards human solid tumors, specifically pancreatic cancers and their …

E Paluszkiewicz, B Horowska, B Borowa-Mazgaj… - European Journal of …, 2020 - Elsevier
New promising unsymmetrical bisacridine derivatives (UAs), have been developed. Three
groups including 36 compounds were synthesized by the condensation of 4-nitro or 4 …

The interactions of monomeric acridines and unsymmetrical bisacridines (UAs) with DNA duplexes: an insight provided by NMR and MD studies

T Laskowski, M Kosno, W Andrałojć, JE Frackowiak… - Scientific Reports, 2023 - nature.com
Members of a novel class of anticancer compounds, exhibiting high antitumor activity, ie the
unsymmetrical bisacridines (UAs), consist of two heteroaromatic ring systems. One of the …

Amino acid or peptide conjugates of acridine/acridone and quinoline/quinolone-containing drugs. A critical examination of their clinical effectiveness within a twenty …

M Kukowska - European Journal of Pharmaceutical Sciences, 2017 - Elsevier
Abstract Acridines/acridones, quinolines/quinolones (chromophores) and their derivatives
constitute extremely important family of compounds in current medicine. Great significance …

Fused xanthone derivatives as antiproliferative agents

N Pouli, P Marakos - Anti-Cancer Agents in Medicinal …, 2009 - ingentaconnect.com
Xanthones have been isolated from several natural sources, mainly belonging in Guttiferae
and Gentianaceae families as secondary plant metabolites and many of them are endowed …

Biological evaluation and molecular docking studies of nitro benzamide derivatives with respect to in vitro anti-inflammatory activity

TB Tumer, FC Onder, H Ipek, T Gungor… - International …, 2017 - Elsevier
A series of nitro substituted benzamide derivatives were synthesized and evaluated for their
potential anti-inflammatory activities in vitro. Firstly, all compounds (1–6) were screened for …

Synthesis and antitumor activity of conjugates of muramyldipeptide or normuramyldipeptide with hydroxyacridine/acridone derivatives

K Dzierzbicka, AM Kołodziejczyk - Journal of medicinal chemistry, 2003 - ACS Publications
A series of MDP (muramyldipeptide) or nor-MDP (normuramyldipeptide) analogues modified
at the C-terminus post of the molecule by a formation of an ester bond between the …