We address adaptive vs. maladaptive responses to hypoxemia in healthy humans and
hypoxic-tolerant species during wakefulness, sleep, and exercise. Types of hypoxemia …

Rationale: Obesity leads to resistant hypertension and mechanisms are poorly understood,
but high plasma levels of leptin have been implicated. Leptin increases blood pressure …

The past decade has provided major advances in our understanding of chemoreception: its
basic mechanisms of transduction; its role in cardiorespiratory regulation in wakefulness …

Carotid body pathophysiology is associated with many cardiovascular–respiratory–
metabolic diseases. This pathophysiology reflects both hyper‐sensitivity and hyper‐tonicity …

Early life over-nutrition, as experienced in maternal obesity, is a risk factor for developing
cardiorespiratory and metabolic diseases. Here we investigated the effects of high-fat diet …

The combination of hypoxia and hypercapnia during sleep produces arousal, which helps
restore breathing and normalizes blood gases. Hypercapnia and hypoxia produce arousal …

Chronic exposure to intermittent hypoxia (CIH) elicits plasticity of the carotid sinus and
phrenic nerves via reactive oxygen species (ROS). To determine whether CIH-induced …

We examined ventilatory acclimatization to hypoxia (VAH) in CD1 mice, and contrasted
results obtained using the barometric method on unrestrained mice with …

Compared with acyanotic congenital heart disease (CHD), cyanotic CHD has an increased
risk of lifelong mortality and morbidity. These adverse outcomes may be attributed to …

Key points In the present study, we provide evidence for divergent physiological responses
to moderate compared to severe hypoxia, addressing an important knowledge gap related …