Non-alcoholic fatty liver disease (NAFLD), currently the leading cause of global chronic liver
disease, has emerged as a major public health problem, more efficient therapeutics of which …

Since 1985, the thiazolidinedione pioglitazone has been widely used as an insulin
sensitizer drug for type 2 diabetes mellitus (T2DM). Although fluid retention was early …

UV irradiation acts as a broad activator of cell surface growth factor and cytokine receptors.
This ligand-independent receptor activation induces multiple downstream signaling …

Based on the fact that aging is associated with a reciprocal decrease of osteogenesis and
an increase of adipogenesis in bone marrow and that osteoblasts and adipocytes share a …

Introduction Smad‐3, a key cytoplasmic mediator of transforming growth factor‐β (TGF‐β)
signalling, mediates many of its inflammatory and fibrotic effects in vivo (Roberts et al. 2001) …

Members of the transforming growth factor‐β (TGF‐β) superfamily bind to two different
serine/threonine kinase receptors, ie type I and type II receptors. Upon ligand binding, type I …

Alcoholic hepatitis (AH) is a life-threatening condition characterized by profound
hepatocellular dysfunction for which targeted treatments are urgently needed. Identification …

Mortality that results from the common forms of cancer is still unacceptably high. Despite
immense advances in the understanding of the mechanisms of carcinogenesis, in bringing …

Depletion of peroxisome proliferator-activated receptor γ (PPARγ) accompanies
myofibroblastic transdifferentiation of hepatic stellate cells (HSC), the primary cellular event …

Connective tissue growth factor (CTGF) has recently received much attention as a possible
key determinant of progressive fibrosis and excessive scarring and also of wound repair …