Phagocytes such as neutrophils play a vital role in host defense against microbial
pathogens. The anti-microbial function of neutrophils is based on the production of …

Due to the growing importance of cellular signaling mediated by reactive oxygen species
(ROS), proteins that are reversibly modulated by these reactant molecules are of high …

Professional phagocytes (neutrophils, eosinophils, monocytes and macrophages) possess
an enzymatic complex, the NADPH oxidase, which is able to catalyze the one‐electron …

Reactive oxygen species (ROS) have long been studied in the context of their direct toxic
effects on cells. As a result, ROS have conventionally been thought of as a necessary …

The respiratory burst oxidase catalyzes the production of O2.-from oxygen and NADPH. It is
dormant in resting cells but becomes active when the cells are stimulated. Activation is …

Generation of superoxide anion by the multiprotein complex NADPH phagocyte oxidase is
accompanied by extensive phosphorylation of its 47-kDa protein component, p47 phox, a …

The respiratory burst oxidase is responsible for superoxide (O 2) production by phagocytes
and B lymphocytes. This multicomponent enzyme is dormant in resting cells but is activated …

Reactive oxygen species are a critical weapon in the killing of Aspergillus fumigatus by
polymorphonuclear leukocytes (PMN), as demonstrated by severe aspergillosis in chronic …

The neutrophils constitute the largest population of white blood cells and the first line of
defense of mammalian organisms against invading microbes. They circulate passively in the …

A clinical syndrome characterized by recurrent life-threatening Staphylococcus aureus,
Proteus or Pseudomonas sepsis, hypergammaglobulinaemia, and widespread chronic …