Historically, the thalamus has been viewed as little more than a relay, simply transferring
information to key players of the cast, the cortex and hippocampus, without providing any …

The outcome of a decision is often uncertain, and outcomes can vary over repeated
decisions. Whether decision outcomes should substantially affect behaviour and learning …

Deficits in cognition are a core feature of many psychiatric conditions, including
schizophrenia, where the severity of such deficits is a strong predictor of long-term outcome …

The function of the human mediodorsal thalamic nucleus (MD) has so far eluded a clear
definition in terms of specific cognitive processes and tasks. Although it was at first proposed …

Paranoia is the belief that harm is intended by others. It may arise from selective pressures
to infer and avoid social threats, particularly in ambiguous or changing circumstances. We …

Computational modeling of brain mechanisms of cognition has largely focused on the
cortex, but recent experiments have shown that higher-order nuclei of the thalamus …

The mediodorsal nucleus of the thalamus (MD) has been implicated in executive functions
(such as planning, cognitive control, working memory, and decision-making) because of its …

Abstract Knowledge about the relevance of environmental features can guide stimulus
processing. However, it remains unclear how processing is adjusted when feature relevance …

The mediodorsal thalamus (MD) and anterior thalamic nuclei (ATN) are two adjacent brain
nodes that support our ability to make decisions, learn, update information, form and retrieve …

Impairments in response inhibition and salience attribution (iRISA) have been proposed to
underlie the clinical symptoms of drug addiction as mediated by cortico-striatal-thalamo …