l-Carnitine and Acetyl-l-carnitine Roles and Neuroprotection in Developing Brain

GC Ferreira, MC McKenna - Neurochemical research, 2017 - Springer
Abstract l-Carnitine functions to transport long chain fatty acyl-CoAs into the mitochondria for
degradation by β-oxidation. Treatment with l-carnitine can ameliorate metabolic imbalances …

Mitochondrial function in spinal cord injury and regeneration

PG Slater, ME Domínguez-Romero, M Villarreal… - Cellular and Molecular …, 2022 - Springer
Many people around the world suffer from some form of paralysis caused by spinal cord
injury (SCI), which has an impact on quality and life expectancy. The spinal cord is part of …

Effects of supplemental dietary L-carnitine and bile acids on growth performance, antioxidant and immune ability, histopathological changes and inflammatory …

M Jin, T Pan, X Cheng, TT Zhu, P Sun, F Zhou, X Ding… - Aquaculture, 2019 - Elsevier
Numerous studies have demonstrated that l-carnitine (LC) and bile acids (BA) could improve
growth performance, reduce fat deposition and affect the inflammatory response in fish …

Effects of mitochondrial transplantation on bioenergetics, cellular incorporation, and functional recovery after spinal cord injury

JL Gollihue, SP Patel, KC Eldahan, DH Cox… - Journal of …, 2018 - liebertpub.com
Our previous studies reported that pharmacological maintenance of mitochondrial
bioenergetics after experimental spinal cord injury (SCI) provided functional …

[HTML][HTML] Cellular and subcellular oxidative stress parameters following severe spinal cord injury

NP Visavadiya, SP Patel, JL VanRooyen, PG Sullivan… - Redox biology, 2016 - Elsevier
The present study undertook a comprehensive assessment of the acute biochemical
oxidative stress parameters in both cellular and, notably, mitochondrial isolates following …

Neuroprotection in acute brain injury: an up-to-date review

N Stocchetti, FS Taccone, G Citerio, PE Pepe… - Critical care, 2015 - Springer
Neuroprotective strategies that limit secondary tissue loss and/or improve functional
outcomes have been identified in multiple animal models of ischemic, hemorrhagic …

N-Acetylaspartate reductions in brain injury: impact on post-injury neuroenergetics, lipid synthesis, and protein acetylation

JR Moffett, P Arun, PS Ariyannur… - Frontiers in …, 2013 - frontiersin.org
N-Acetylaspartate (NAA) is employed as a non-invasive marker for neuronal health using
proton magnetic resonance spectroscopy (MRS). This utility is afforded by the fact that NAA …

Mitochondrial biogenesis as a therapeutic target for traumatic and neurodegenerative CNS diseases

EC Simmons, NE Scholpa, RG Schnellmann - Experimental neurology, 2020 - Elsevier
Central nervous system (CNS) diseases, both traumatic and neurodegenerative, are
characterized by impaired mitochondrial bioenergetics and often disturbed mitochondrial …

Mitochondrial-based therapeutics for the treatment of spinal cord injury: mitochondrial biogenesis as a potential pharmacological target

NE Scholpa, RG Schnellmann - Journal of Pharmacology and Experimental …, 2017 - ASPET
Spinal cord injury (SCI) is characterized by an initial trauma followed by a progressive
cascade of damage referred to as secondary injury. A hallmark of secondary injury is …

N-acetylcysteine amide preserves mitochondrial bioenergetics and improves functional recovery following spinal trauma

SP Patel, PG Sullivan, JD Pandya, GA Goldstein… - Experimental …, 2014 - Elsevier
Mitochondrial dysfunction is becoming a pivotal target for neuroprotective strategies
following contusion spinal cord injury (SCI) and the pharmacological compounds that …