Tumor-on-a-chip model for advancement of anti-cancer nano drug delivery system

C Tian, S Zheng, X Liu, K Kamei - Journal of Nanobiotechnology, 2022 - Springer
Despite explosive growth in the development of nano-drug delivery systems (NDDS)
targeting tumors in the last few decades, clinical translation rates are low owing to the lack of …

In situ biosensing technologies for an organ-on-a-chip

J Kim, J Kim, Y Jin, SW Cho - Biofabrication, 2023 - iopscience.iop.org
The in vitro simulation of organs resolves the accuracy, ethical, and cost challenges
accompanying in vivo experiments. Organoids and organs-on-chips have been developed …

Application of 3D bioprinting in liver diseases

W Li, Z Liu, F Tang, H Jiang, Z Zhou, X Hao, JM Zhang - Micromachines, 2023 - mdpi.com
Liver diseases are the primary reason for morbidity and mortality in the world. Owing to a
shortage of organ donors and postoperative immune rejection, patients routinely suffer from …

Supramolecular Stability of Benzene-1, 3, 5-Tricarboxamide Supramolecular Polymers in Biological Media: Beyond the Stability–Responsiveness Trade-Off

E Fuentes, Y Gabaldón, M Collado… - Journal of the …, 2022 - ACS Publications
Supramolecular assemblies have been gaining attention in recent years in the field of drug
delivery because of their unique formulation possibilities and adaptive behavior. Their non …

Recent advances in vascularized tumor-on-a-chip

CBX Huang, TY Tu - Frontiers in Oncology, 2023 - frontiersin.org
The vasculature plays a critical role in cancer progression and metastasis, representing a
pivotal aspect in the creation of cancer models. In recent years, the emergence of organ-on …

Self-Report Amphiphilic Polymer-Based Drug Delivery System with ROS-Triggered Drug Release for Osteoarthritis Therapy

S Tang, Y Gao, W Wang, Y Wang, P Liu… - ACS Macro …, 2023 - ACS Publications
The development of drug delivery systems with real-time cargo release monitoring
capabilities is imperative for optimizing nanomedicine performance. Herein, we report an …

[HTML][HTML] Bioprinting of Cells, Organoids and Organs-on-a-Chip Together with Hydrogels Improves Structural and Mechanical Cues

CT Mierke - Cells, 2024 - pmc.ncbi.nlm.nih.gov
The 3D bioprinting technique has made enormous progress in tissue engineering,
regenerative medicine and research into diseases such as cancer. Apart from individual …

Three-dimensional culture models: emerging platforms for screening the antitumoral efficacy of nanomedicines

LB Tofani, MT Luiz, JA Paes Dutra, JP Abriata… - …, 2023 - Taylor & Francis
Nanomedicines have been investigated for delivering drugs to tumors due to their ability to
accumulate in the tumor tissues. 2D in vitro cell culture has been used to investigate the …

Reaching the Tumor: Mobility of Polymeric Micelles Inside an In Vitro Tumor-on-a-Chip Model with Dual ECM

AR Olea, A Jurado, G Slor, S Tevet… - … applied materials & …, 2023 - ACS Publications
Degradable polymeric micelles are promising drug delivery systems due to their
hydrophobic core and responsive design. When applying micellar nanocarriers for tumor …

Stimuli-Induced Architectural Transition as a Tool for Controlling the Enzymatic Degradability of Polymeric Micelles

G Slor, S Tevet, RJ Amir - ACS Polymers Au, 2022 - ACS Publications
Enzyme-responsive polymeric micelles hold great potential as drug delivery systems due to
the overexpression of disease-associated enzymes. To achieve selective and efficient …