Several recent studies have identified nuclear factor-κB as a key modulator in driving
inflammation to cancers. Besides this transcription factor, essential in regulating …

It is now possible to grow DC-like cells in culture17-21 and extensive cell membrane
processes that are acquired late the first monoclonal antibodies (MoAbs) 22, 23 that react …

The potential to harness the potency and specificity of the immune system underlies the
growing interest in cancer immunotherapy. One such approach uses bone marrow–derived …

Cytotoxic T lymphocytes (CTLs) are a critical component of the immune response to tumors.
Tumor-derived peptide antigens targeted by CTLs are being defined for several human …

Chemokines participate, by regulating cell trafficking and controlling angiogenesis, in the
host response during infection and inflammation. Most of these mechanisms are also …

Publisher Summary This chapter provides an overview of dendritic cells (DCs). Dendritic
cells were first identified in the epidermis and were termed “Langerhans cells.” DCs are now …

Leucocytes are a major component of the tumour microenvironment. Recent studies have
indicated that the infiltration and activity of these host cells are regulated by the tumour to …

Dendritic cells (DC) are central to the initiation of immunity. To induce immune reactivity, DC
are recruited at the site of antigen expression, uptake antigens and migrate to secondary …

Dendritic cells (DCs) are predicted to participate in natural tumor immunity by migrating into
tumors, where they acquire antigen, undergo activation, and migrate to lymph nodes to …

BACKGROUND Dendritic cells (DCs) are antigen‐presenting cells with a unique ability to
cross prime T cells and generate strong antitumor responses. This study evaluates the …