Exposure of rodents to an enriched environment (EE) has been shown to reliably increase
performance on hippocampus-dependent learning and memory tasks, compared to …

Background: As the human lifespan increases, the number of people affected by agerelated
dementia is growing at an epidemic pace. Vascular pathology dramatically affects cognitive …

The extracellular matrix (ECM) plays diverse roles in several physiological and pathological
conditions. In the brain, the ECM is unique both in its composition and in functions …

Background Chronic cerebral hypoperfusion (CCH) is a frequently observed underlying
pathology of both Alzheimer's disease (AD) and vascular dementia (VD), which is a common …

Fingolimod (FTY720) is a known sphingosine-1-phosphate (S1P) receptor agonist. Several
studies have shown the therapeutic efficacy of FTY720 in neurodegenerative disorders …

Environmental enrichment (EE) has shown remarkable effects in improving cognition and
addictive behaviour. We tested whether EE could help recover from prenatal stress …

The opioid epidemic is a rapidly evolving societal issue driven, in part, by a surge in
synthetic opioid use. A rise in fentanyl use among pregnant women has led to a 40-fold …

Background This study was designed to explore the beneficial effects of environmental
enrichment (EE) on white matter glial changes in a mouse model of chronic cerebral …

Background Recently, TDP-43 has been recognized as a common proteinopathy in the
“oldest old” and a neuropathological comorbidity in patients with Alzheimer's disease (AD) …

Background: Synucleinopathies are disorders characterized by the abnormal accumulation
of α-synuclein (aSyn). Synaptic compromise is observed in synucleinopathies parallel to …