Epigenetic defects caused by hereditary or de novo mutations are implicated in various
human diseases. It remains uncertain whether correcting the underlying mutation can …

In mammals, DNA methylation is an essential epigenetic modification necessary for the
maintenance of genome stability, regulation of gene expression, and other processes …

Outgrowth of a mutated hematopoietic stem/progenitor clone and its descendants, also
known as clonal hematopoiesis, has long been considered as either a potential forerunner …

Screening of a small chemical library (Medicines for Malaria Venture Pathogen Box)
identified two structurally related pyrazolone (inhibitor 1) and pyridazine (inhibitor 2) …

In mammals, de novo methylation of cytosines in DNA CpG sites is performed by DNA
methyltransferase Dnmt3a. Changes in the methylation status of CpG islands are critical for …

Methylcytosine (5mC), the central epigenetic mark of mammalian DNA, plays fundamental
roles in chromatin regulation. 5mC is written onto genomes by DNA methyltransferases …

The development of malignant tumors is caused by a complex combination of genetic
mutations and epigenetic alterations, the latter of which are induced by either external …

Abstract The DNMT3A DNA methyltransferase is an important epigenetic enzyme that is
frequently mutated in cancers, particularly in AML. The heterozygous R736H mutation in the …

The specific regulation of cell metabolism is one of cornerstones of biochemistry. Numerous
lines of evidence have been obtained showing that various pathologies are associated with …

DNA 甲基化的调控异常对恶性血液病的发生发展具有重要影响, 甲基化靶向治疗是现代医学的
主要手段之一, 但仍有诸多问题. 随着中医药对表观遗传学研究的不断进展和" 态靶医学" …