Abstract Ischemia-reperfusion (I/R) injury paradoxically occurs during reperfusion following
ischemia, exacerbating the initial tissue damage. The limited understanding of the intricate …

Acute ST-elevation myocardial infarction (STEMI) and acute ischaemic stroke (AIS) share a
number of similarities. However, important differences in pathophysiology demand a …

Background Whether intravenous thrombolysis (IVT) prior to endovascular thrombectomy
(EVT) provides additional benefits in patients with acute ischemic stroke (AIS) and a large …

The rate of stroke-related death and disability is four times higher in low-and middle-income
countries (LMICs) than in high-income countries (HICs), yet stroke units exist in only 18% of …

Objective In the present study, we conducted a meta-analysis of reported randomized
controlled trials (RCTs) comparing the safety and efficacy of direct thrombectomy (DT) and …

Background Basilar artery occlusion (BAO) stroke is a catastrophic clinical event that results
in significant morbidity and mortality. Whether MT is superior in improving outcomes remains …

Background To this date, whether to administer intravenous thrombolysis (IVT) prior to
endovascular thrombectomy (EVT) for stroke patients still stirs some debate. We aimed to …

Mechanical thrombectomy is a highly effective treatment for acute ischemic stroke caused by
large-vessel occlusion in the anterior cerebral circulation, significantly increasing the …

Objective The current meta-analysis aimed to investigate the efficacy and safety of direct
endovascular treatment (EVT) and bridging therapy (EVT with prior intravenous thrombolysis …

Introduction: In recent years, the role of intravenous thrombolysis (IVT) before endovascular
stroke treatment (EVT) has been discussed intensively. Whether the discussion was …