Tumor-infiltrating regulatory T cells as targets of cancer immunotherapy

C Tay, A Tanaka, S Sakaguchi - Cancer Cell, 2023 - cell.com
Regulatory T cells (Tregs) are abundant in tumor tissues, raising a question of whether
immunosuppressive tumor-infiltrating Tregs (TI-Tregs) can be selectively depleted or …

Transforming growth factor–β1 in regulatory T cell biology

JM Moreau, M Velegraki, C Bolyard… - Science …, 2022 - science.org
Transforming growth factor–β1 (TGF-β1) is inextricably linked to regulatory T cell (Treg)
biology. However, precisely untangling the role for TGF-β1 in Treg differentiation and …

TGF-β signaling and resistance to cancer therapy

M Zhang, YY Zhang, Y Chen, J Wang… - Frontiers in Cell and …, 2021 - frontiersin.org
The transforming growth factor β (TGF-β) pathway, which is well studied for its ability to
inhibit cell proliferation in early stages of tumorigenesis while promoting epithelial …

TGFβ control of immune responses in cancer: a holistic immuno-oncology perspective

BG Nixon, S Gao, X Wang, MO Li - Nature Reviews Immunology, 2023 - nature.com
The immune system responds to cancer in two main ways. First, there are prewired
responses involving myeloid cells, innate lymphocytes and innate-like adaptive lymphocytes …

Defining and using immune archetypes to classify and treat cancer

AJ Combes, B Samad, MF Krummel - Nature Reviews Cancer, 2023 - nature.com
Tumours are surrounded by a host immune system that can suppress or promote tumour
growth. The tumour microenvironment (TME) has often been framed as a singular entity …

Bispecific antibody targeting TGF-β and PD-L1 for synergistic cancer immunotherapy

T Li, X Wang, M Niu, M Wang, J Zhou, K Wu… - Frontiers in …, 2023 - frontiersin.org
The PD-1/PD-L1 signaling pathway plays a crucial role in cancer immune evasion, and the
use of anti-PD-1/PD-L1 antibodies represents a significant milestone in cancer …

[HTML][HTML] TGF-β, EMT, and resistance to anti-cancer treatment

X Wang, PJA Eichhorn, JP Thiery - Seminars in Cancer Biology, 2023 - Elsevier
Transforming growth factor-β (TGF-β) signaling regulates cell-specific programs involved in
embryonic development, wound-healing, and immune homeostasis. Yet, during tumor …

Dynamic allostery drives autocrine and paracrine TGF-β signaling

M Jin, RI Seed, G Cai, T Shing, L Wang, S Ito… - Cell, 2024 - cell.com
TGF-β, essential for development and immunity, is expressed as a latent complex (L-TGF-β)
non-covalently associated with its prodomain and presented on immune cell surfaces by …

Clinical adoptive regulatory T Cell therapy: State of the art, challenges, and prospective

L Amini, J Kaeda, E Fritsche, A Roemhild… - Frontiers in Cell and …, 2023 - frontiersin.org
Rejection of solid organ transplant and graft versus host disease (GvHD) continue to be
challenging in post transplantation management. The introduction of calcineurin inhibitors …

Regulatory T cell-mediated immunosuppression orchestrated by cancer: towards an immuno-genomic paradigm for precision medicine

S Kumagai, K Itahashi, H Nishikawa - Nature Reviews Clinical …, 2024 - nature.com
Accumulating evidence indicates that aberrant signalling stemming from genetic
abnormalities in cancer cells has a fundamental role in their evasion of antitumour immunity …