Abstract Background In Europe cardiovascular disease (CVD) is responsible for 3.9 million
deaths (45% of deaths), being ischaemic heart disease, stroke, hypertension (leading to …

Peroxisome proliferator–activated receptor α (PPAR α) is a nuclear receptor of clinical
interest as a drug target in various metabolic disorders. PPAR α also exhibits marked anti …

The statins have been used for 30 years to prevent coronary artery disease and stroke. Their
primary mechanism of action is the lowering of serum cholesterol through inhibiting hepatic …

In the last few years, PPARs have emerged as key regulators of inflammatory and immune
responses. However, the mechanistic basis of the anti-inflammatory effects of peroxisome …

Background The production of peroxide and superoxide is an inevitable consequence of
aerobic metabolism, and while these particular'reactive oxygen species'(ROSs) can exhibit a …

The peroxisome proliferator-activated receptor α (PPARα, or NR1C1) is a nuclear hormone
receptor activated by a structurally diverse array of synthetic chemicals known as …

Statins are 3-hydroxy-3-methyglutaryl coenzyme A (HMG-CoA) reductase inhibitors, which
are prescribed extensively for cholesterol lowering in the primary and secondary prevention …

Toll-like receptors (TLRs) have a key role in innate immunity. These receptors recognize
both pathogen-associated molecular patterns and molecules that are released from …

A variety of studies have shown that some activated nuclear receptors (NRs), especially the
glucorticoid receptor, the estrogen receptor and peroxisome proliferator-activated receptor …

Peroxisome proliferator-activated receptors (PPARs) belong to the nuclear hormone-
receptor superfamily. Originally cloned in 1990, PPARs were found to be mediators of …