Lipids shape brain function through ion channel and receptor modulations: physiological mechanisms and clinical perspectives
S Incontro, ML Musella, M Sammari… - Physiological …, 2025 - journals.physiology.org
Lipids represent the most abundant molecular type in the brain, with a fat content of∼ 60%
of the dry brain weight in humans. Despite this fact, little attention has been paid to …
of the dry brain weight in humans. Despite this fact, little attention has been paid to …
[HTML][HTML] Modeling the Effect of Cannabinoid Exposure During Human Neurodevelopment Using Bidimensional and Tridimensional Cultures
E Estudillo, JI Castillo-Arellano, E Martínez… - Cells, 2025 - mdpi.com
Our knowledge about the consumption of cannabinoids during pregnancy lacks consistent
evidence to determine whether it compromises neurodevelopment. Addressing this task is …
evidence to determine whether it compromises neurodevelopment. Addressing this task is …
Layer specific regulation of critical period timing and maturation of mouse visual cortex by endocannabinoids
T Yoneda, K Kameyama, T Gotou, K Terata, M Takagi… - iScience, 2024 - cell.com
Plasticity during the critical period is important for the functional maturation of cortical
neurons. While characteristics of plasticity are diverse among cortical layers, it is unknown …
neurons. While characteristics of plasticity are diverse among cortical layers, it is unknown …
[HTML][HTML] From Classical to Alternative Pathways of 2-Arachidonoylglycerol Synthesis: AlterAGs at the Crossroad of Endocannabinoid and Lysophospholipid Signaling
F Briand-Mésange, I Gennero, J Salles, S Trudel… - Molecules, 2024 - mdpi.com
2-arachidonoylglycerol (2-AG) is the most abundant endocannabinoid (EC), acting as a full
agonist at both CB1 and CB2 cannabinoid receptors. It is synthesized on demand in …
agonist at both CB1 and CB2 cannabinoid receptors. It is synthesized on demand in …
Deletion of endocannabinoid synthesizing enzyme DAGLα from cerebellar Purkinje cells decreases social preference and elevates anxiety
G Smith, K McCoy, G Viana Di Prisco, A Kuklish… - bioRxiv, 2024 - biorxiv.org
The endocannabinoid (eCB) signaling system is robustly expressed in the cerebellum
starting from the embryonic developmental stages to adulthood. There it plays a key role in …
starting from the embryonic developmental stages to adulthood. There it plays a key role in …