Over 20 years ago, it was first proposed that autoinflammation underpins a handful of rare
monogenic disorders characterized by recurrent fever and systemic inflammation. The …

Bone remodeling is tightly controlled by osteoclast-mediated bone resorption and osteoblast-
mediated bone formation. Fine tuning of the osteoclast–osteoblast balance results in strict …

Inflammasomes are multiprotein innate immune complexes that regulate caspase-
dependent inflammation and cell death. Pattern recognition receptors, such as nucleotide …

Inflammasomes are a group of multimolecular intracellular complexes assembled around
several innate immune proteins. Recognition of a diverse range of microbial, stress and …

Cryopyrin-associated periodic syndrome (CAPS) is a rare inherited autoinflammatory
disorder characterized by systemic, cutaneous, musculoskeletal, and central nervous system …

The autoinflammatory diseases are characterized by seemingly unprovoked episodes of
inflammation, without high-titer autoantibodies or antigen-specific T cells. The concept was …

Objectives Inflammasomes are multiprotein complexes that sense pathogens and trigger
biological mechanisms to control infection. Nucleotide-binding oligomerisation domain-like …

Inflammasomes are multiprotein complexes that critically control different aspects of innate
and adaptive immunity. Among them we could highlight the release of pro-inflammatory …

Inflammation, a vital response of the immune system to infection and damage to tissues, can
be initiated by various germline-encoded innate immune-signaling receptors. Among these …

The objective of this work was to develop and validate a set of clinical criteria for the
classification of patients affected by periodic fevers. Patients with inherited periodic fevers …