The recent expansion of multidrug resistant and pan-drug-resistant pathogens poses
significant challenges in the treatment of healthcare associated infections. An important …

Over the last several decades, antibacterial drug use has become widespread with their
misuse being an ever-increasing phenomenon. Consequently, antibacterial drugs have …

The scourge of antibiotic resistance threatens modern healthcare delivery. A contributing
factor to this significant issue may be antibiotic dosing, whereby standard antibiotic regimens …

Background Amikacin is an aminoglycoside commonly used in intensive care units for the
treatment of patients with life-threatening Gram-negative infections. Although …

Introduction: The emergence of carbapenem-resistant Enterobacteriaceae (CRE) has
brought aminoglycosides to the frontline since an aminoglycoside may be the only …

Amikacin has been one of the important antimicrobial agents against Gram-negative
pathogens. However, there is discrepancy regarding the amikacin initial dosage, with some …

Background Amikacin infusion requires targeting a peak serum concentration (C max) 8–10
times the minimal inhibitory concentration, corresponding to a C max of 60–80 mg/L for the …

Purpose Vancomycin is commonly used for the management of severe infections; however,
vancomycin dosing may be challenging in critically ill patients. This observational study aims …

Purpose: The aim of this study is to improve the anti-biofilm activity of antibiotics. We
hypothesized that the antimicrobial peptide (AMP) complex of the host's immune system can …

We report on the pharmacokinetics (PK) and pharmacodynamics (PD) of high-dose (> 15
mg/kg of body weight per day) amikacin. A mean (standard deviation [SD]) maximum drug …