BACKGROUND Meiosis is an essential stage in the life cycle of sexually reproducing
species, underlying formation of haploid gametes and serving as the basis of genetic …

In mammalian male meiosis, the heterologous X and Y chromosomes remain unsynapsed
and, as a result, are subject to meiotic sex chromosome inactivation (MSCI). MSCI is …

Male gametes are generated through a specialised differentiation pathway involving a
series of developmental transitions that are poorly characterised at the molecular level …

Spermatogenesis is highly orchestrated and involves the differentiation of diploid
spermatogonia into haploid sperm. The process is driven by spermatogonial stem cells …

During meiotic prophase I, spermatocytes must balance transcriptional activation with
homologous recombination and chromosome synapsis, biological processes requiring …

Abstract N6-methyladenosine (m6A) and its reader proteins YTHDC1, YTHDC2, and
YTHDF2 have been shown to exert essential functions during spermatogenesis. However …

Meiotic sex chromosome inactivation (MSCI) is an essential process in the male germline.
While genetic experiments have established that the DNA damage response (DDR) …

Pachynema progression contributes to the completion of prophase I. Nevertheless, the
regulation of this significant meiotic process remains poorly understood. In this study, we …

Meiotic crossovers are required for the faithful segregation of homologous chromosomes
and to promote genetic diversity. However, it is unclear how crossover formation is …

Heterochromatin is a critical chromatin compartment, whose integrity governs genome
stability and cell fate transitions. How heterochromatin features, including higher-order …