Gβγ subunits from heterotrimeric G proteins perform a vast array of functions in cells with
respect to signaling, often independently as well as in concert with Gα subunits. However …

Our vasculature plays diverse and critical roles in homeostasis and disease. In recent
decades, the use of zebrafish has driven our understanding of vascular development into …

The mechanisms by which multiple myeloma (MM) cells migrate and home to the bone
marrow are not well understood. In this study, we sought to determine the effect of the …

Colorectal cancer (CRC) is the most common malignant tumor of digestive system. The aim
of this study was to identify gene signatures during CRC and uncover their potential …

Rationale: Pulmonary arterial hypertension (PAH) is a progressive fatal disease. Variable
response and tolerability to PAH therapeutics suggests that genetic differences may …

Vertebrate cones and rods in several cases use separate but related components for their
signal transduction (opsins, G-proteins, ion channels, etc.). Some of these proteins are also …

Although the zebrafish model provides an important platform for the study of developmental
biology, recent work with the zebrafish model has extended its application to a wide variety …

Diabetic foot ulcers cause great suffering and are costly for the healthcare system. Normal
wound healing involves hemostasis, inflammation, proliferation, and remodeling. However …

G-protein gamma subunit 2 (GNG2) is involved in several cell signaling pathways, and is
essential for cell proliferation and angiogenesis. However, the role of GNG2 in …

Angiogenesis, the formation of new blood vessels from pre-existing ones, is essential for
development, wound healing, and tumor progression. The VEGF pathway plays …