Pancreatic cancer is a leading cause of cancer death worldwide and its global burden has
more than doubled over the past 25 years. The highest incidence regions for pancreatic …

This review aims to summarize the latest knowledge on factors, diagnosis, and treatment of
pancreatic cancer, and aims to promote further research on this under-studied malignant …

Although discussion of the obesity epidemic had become a cocktail party cliché, its impact
on public health cannot be dismissed. In the past decade, cancer had joined the list of …

Abstract In 2020, 146,063 deaths due to pancreatic cancer are estimated to occur in Europe
and the United States combined. To identify common susceptibility alleles, we performed the …

Activation of the ATR kinase following perturbations to DNA replication relies on a complex
mechanism involving ATR recruitment to RPA-coated single-stranded DNA via its binding …

The ATR checkpoint kinase coordinates cellular responses to DNA replication stress.
Budding yeast contain three activators of Mec1 (the ATR orthologue); however, only …

We performed a multistage genome-wide association study including 7,683 individuals with
pancreatic cancer and 14,397 controls of European descent. Four new loci reached genome …

Genome-wide association studies have identified several loci associated with pancreatic
cancer risk; however, the mechanisms by which genetic factors influence the development of …

Expression quantitative trait locus (eQTL) analysis, which links variations in gene expression
to genotypes, is essential to understanding gene regulation and to interpreting disease …

Pancreatic cancer is the fourth leading cause of cancer death in the developed world. Both
inherited high-penetrance mutations in BRCA2 (ref.), ATM, PALB2 (ref.), BRCA1 (ref.) …