Successful regeneration of large segmental bone defects remains a major challenge in
clinical orthopedics, thus it is of important significance to fabricate a suitable alternative …

Bone tissue engineering is a highly interdisciplinary field that seeks to tackle the most
challenging bone-related clinical issues. The major components of bone tissue engineering …

Ageing, which all creatures must encounter, is a challenge to every living organism. In the
human body, it is estimated that cell division and metabolism occurs exuberantly until about …

Aim: Silencing information regulator (SirT1), a NAD-dependent histone deacetylase, is an
essential mediator of longevity in normal cells by calorie restriction. SirT1 has many …

Osteogenic differentiation of multipotent mesenchymal stem cells (MSCs) plays a crucial role
in bone remodeling. Numerous studies have described the deleterious effect of iron …

Ischemic stroke is the leading cause of disability in the world. Cell transplantation has
emerged in various neurological diseases as a potential therapeutic approach in the …

Higher levels of body fat are associated with increased risk for development of numerous
adverse health conditions. Phytochemicals are potential agents to inhibit differentiation of …

Mesenchymal stem cells (MSCs) have become one of the most promising cell sources for
bone tissue engineering (BTE) applications. In this review, we first highlight recent progress …

Induced pluripotent stem cells (iPSCs) can differentiate into mineralizing cells and thus have
a great potential in application in engineered bone substitutes with bioactive scaffolds in …

Bone regeneration is a complex process that is influenced by tissue interactions,
inflammatory responses, and progenitor cells. Diseases, lifestyle, or multiple trauma can …