In primary Sjögren syndrome (pSS), the function of the salivary glands is often considerably
reduced. Multiple innate immune pathways are likely dysregulated in the salivary gland …

CD40 is a TNF receptor superfamily member expressed on both immune and non-immune
cells. Interactions between B cell-expressed CD40 and its binding partner, CD40L …

Sjögren syndrome (SS) is a common autoimmune disease evidenced by broad organ-
specific and systemic manifestations, the most prevalent being diminished lacrimal and …

Summary Background Primary Sjögren's syndrome is an autoimmune disease that presents
as dryness of the mouth and eyes due to impairment of the exocrine glands. To our …

Sex characteristics exhibit significant disparities in various human diseases, including
prevalent cardiovascular diseases, cancers, metabolic disorders, autoimmune diseases …

Sjögren's syndrome (SjS) is a systemic autoimmune disease, characterized by the presence
of periductal lymphocytic infiltrations in salivary and lachrymal glands resulting in oral and …

Objective Primary Sjögren's syndrome (pSS) is characterised by chronic hyperactivation of B
lymphocytes. Salivary gland epithelial cells (SGECs) could play a role in promoting B …

Sjögren's syndrome (SS), a chronic autoimmune disorder, particularly compromises the
function of exocrine glands. The involvement of these glands is characterized by focal …

During host immune response, an initial and sufficient activation is required to avoid
infection and cancer, yet an excessive activation bears the risk of autoimmune reactivity and …

Sjögren's syndrome (SS) is a chronic autoimmune disorder that is characterized by
dysfunction and destruction of the exocrine glands. Exocrinopathy is associated with …