M Etzel, M Mörl - Biochemistry, 2017 - ACS Publications
In synthetic biology, metabolic engineering, and gene therapy, there is a strong demand for orthogonal or externally controlled regulation of gene expression. Here, RNA-based …
Aptamer biosensor that can switch its structure upon target binding offers a powerful strategy for molecular detection. However, the process of converting an aptamer into a “structure …
R Lentini, NY Martín, SS Mansy - Current opinion in chemical biology, 2016 - Elsevier
Highlights•Artificial cells can be made to sense and respond to the environment, including the presence of natural cells.•One significant limitation to the advancement of artificial cells …
L Cheng, EN White, NL Brandt, AM Yu… - Nucleic acids …, 2022 - academic.oup.com
RNA folds cotranscriptionally to traverse out-of-equilibrium intermediate structures that are important for RNA function in the context of gene regulation. To investigate this process …
Highlights•Unique properties of RNA lead to the development of RNA-based dynamic genetic controllers.•Natural riboswitches are re-engineered to detect new molecules.•RNA …
Food fraudulence and food contamination are major concerns, particularly among consumers with specific dietary, cultural, lifestyle, and religious requirements. Current food …
Aptamers are chemically synthesized oligonucleotides or peptides with molecular recognition capabilities. We investigated recognition of substrate-tethered small-molecule …
KA Rotstan, MM Abdelsayed, LFM Passalacqua… - Elife, 2020 - elifesciences.org
Optogenetic tools have revolutionized the study of receptor-mediated processes, but such tools are lacking for RNA-controlled systems. In particular, light-activated regulatory RNAs …