Aptamers are single-stranded, synthetic oligonucleotides that fold into 3-dimensional
shapes capable of binding non-covalently with high affinity and specificity to a target …

In synthetic biology, metabolic engineering, and gene therapy, there is a strong demand for
orthogonal or externally controlled regulation of gene expression. Here, RNA-based …

Aptamer biosensor that can switch its structure upon target binding offers a powerful strategy
for molecular detection. However, the process of converting an aptamer into a “structure …

Highlights•Recently developed genome engineering tools facilitate pathway control.•Novel
genetic regulators enable multi-level static and dynamic control.•State-of-the-art applications …

Highlights•Artificial cells can be made to sense and respond to the environment, including
the presence of natural cells.•One significant limitation to the advancement of artificial cells …

RNA folds cotranscriptionally to traverse out-of-equilibrium intermediate structures that are
important for RNA function in the context of gene regulation. To investigate this process …

Highlights•Unique properties of RNA lead to the development of RNA-based dynamic
genetic controllers.•Natural riboswitches are re-engineered to detect new molecules.•RNA …

Food fraudulence and food contamination are major concerns, particularly among
consumers with specific dietary, cultural, lifestyle, and religious requirements. Current food …

Aptamers are chemically synthesized oligonucleotides or peptides with molecular
recognition capabilities. We investigated recognition of substrate-tethered small-molecule …

Optogenetic tools have revolutionized the study of receptor-mediated processes, but such
tools are lacking for RNA-controlled systems. In particular, light-activated regulatory RNAs …