The first matrix metalloproteinase (MMP) was discovered in 1962 from the tail of a tadpole by
its ability to degrade collagen. As their name suggests, matrix metalloproteinases are …

Tumor growth and metastasis rely on tumor vascular network for the adequate supply of
oxygen and nutrients. Tumor angiogenesis relies on a highly complex program of growth …

Tumor microenvironment is a complex system that contains multiple cells and cytokines.
Among the multiple immune cells, macrophage is particularly abundant and plays an …

The pursuit of matrix metalloproteinase (MMP) inhibitors began in earnest over three
decades ago. Initial clinical trials were disappointing, resulting in a negative view of MMPs …

Macrophages are crucial innate immune cells that maintain tissue homeostasis and defend
against pathogens; however, their infiltration into tumors has been associated with adverse …

Membrane-type matrix metalloproteinases (MT-MMPs) form a subgroup of the matrix
metalloproteinase (MMP) family, and there are 6 MT-MMPs in humans. MT-MMPs are further …

The extracellular matrix (ECM) is a key regulator of cell and tissue function. Traditionally, the
ECM has been thought of primarily as a physical scaffold that binds cells and tissues …

Matrix metalloproteinases (MMPs) were discovered because of their role in amphibian
metamorphosis, yet they have attracted more attention because of their roles in disease …

The extracellular matrix (ECM) is critical for all aspects of vascular biology. In concert with
supporting cells, endothelial cells (ECs) assemble a laminin-rich basement membrane …

Angiogenesis, or the formation of new blood vessels from the preexisting vasculature, is a
key component in numerous physiologic and pathologic responses and has broad impact in …