Many cellular processes require large-scale rearrangements of chromatin structure.
Structural maintenance of chromosomes (SMC) protein complexes are molecular machines …

During mitosis, the condensin I and II complexes compact chromatin into chromosomes.
Loss of the chromokinesin, KIF4A, results in reduced condensin I association with …

Genomic DNA inside the cell's nucleus is highly organized and tightly controlled by the
structural maintenance of chromosomes (SMC) protein complexes. These complexes fold …

Abstract The 16-subunit Constitutive Centromere-associated Network (CCAN)-based inner
kinetochore is well-known for connecting centromeric chromatin to the spindle-binding outer …

X chromosome inactivation (XCI) generates clonal heterogeneity within XX individuals.
Combined with sequence variation between human X chromosomes, XCI gives rise to intra …

The ring-shaped Cohesin complex, consisting of core subunits Smc1, Smc3, Scc1, and SA2
(or its paralog SA1), topologically entraps two duplicated sister DNA molecules to establish …

Sister chromatid cohesion is mediated by the cohesin complex. In mitotic prophase cohesin
is removed from chromosome arms in a Wapl-and phosphorylation-dependent manner …

Ankyrin Repeat Domain-containing Protein 11 (ANKRD11) is a causative gene for KBG
syndrome, a significant risk factor for Cornelia de Lange syndrome (CdLS), and a highly …

Genomes are organised into DNA loops by the Structural Maintenance of Chromosomes
(SMC) proteins. SMCs establish functional chromosomal sub-domains for DNA repair, gene …

Chromosomes in eukaryotic cells undergo compaction at multiple levels and are folded into
hierarchical structures to fit into the nucleus with limited dimensions. Three-dimensional …