Recent advances in cell penetrating peptide-based anticancer therapies

J Habault, JL Poyet - Molecules, 2019 - mdpi.com
Cell-penetrating-peptides (CPPs) are small amino-acid sequences characterized by their
ability to cross cellular membranes. They can transport various bioactive cargos inside cells …

Cell penetrating peptides: the potent multi-cargo intracellular carriers

K Kardani, A Milani, S H. Shabani… - Expert opinion on drug …, 2019 - Taylor & Francis
ABSTRACT Introduction: Cell penetrating peptides (CPPs) known as protein translocation
domains (PTD), membrane translocating sequences (MTS), or Trojan peptides (TP) are able …

Cell-penetrating peptide: a means of breaking through the physiological barriers of different tissues and organs

J Xu, AR Khan, M Fu, R Wang, J Ji, G Zhai - Journal of Controlled Release, 2019 - Elsevier
The selective infiltration of cell membranes and tissue barriers often blocks the entry of most
active molecules. This natural defense mechanism prevents the invasion of exogenous …

Cell-penetrating peptides enhance peptide vaccine accumulation and persistence in lymph nodes to drive immunogenicity

CM Backlund, RL Holden… - Proceedings of the …, 2022 - National Acad Sciences
Peptide-based cancer vaccines are widely investigated in the clinic but exhibit modest
immunogenicity. One approach that has been explored to enhance peptide vaccine potency …

[HTML][HTML] Potential of cell-penetrating peptides (CPPs) in delivery of antiviral therapeutics and vaccines

I Sadeghian, R Heidari, S Sadeghian, MJ Raee… - European Journal of …, 2022 - Elsevier
Viral infections are a great threat to human health. Currently, there are no effective vaccines
and antiviral drugs against the majority of viral diseases, suggesting the need to develop …

p28-functionalized PLGA nanoparticles loaded with gefitinib reduce tumor burden and metastases formation on lung cancer

AR Garizo, F Castro, C Martins, A Almeida… - Journal of Controlled …, 2021 - Elsevier
Lung cancer is still the main cause of cancer-related deaths worldwide. Its treatment
generally includes surgical resection, immunotherapy, radiotherapy, and chemo-targeted …

Nanoparticles to improve the efficacy of peptide-based cancer vaccines

AL Tornesello, M Tagliamonte, ML Tornesello… - Cancers, 2020 - mdpi.com
Nanoparticles represent a potent antigen presentation and delivery system to elicit an
optimal immune response by effector cells targeting tumor-associated antigens expressed …

[HTML][HTML] Multifunctional building elements for the construction of peptide drug conjugates

L Xu, S Xu, T Xiang, H Liu, L Chen, B Jiang… - Engineered …, 2022 - Elsevier
Engineering of smart building molecules is key basis in designing intelligent drug delivery
systems. As an emerging sophisticated delivery system strategy, the powerful functions of …

[图书][B] CPP, cell-penetrating peptides

Ü Langel - 2019 - Springer
The genesis of cell-penetrating peptide research (CPP; also known as prote/peptide
transduction domains, PTD, or Trojan peptides) was born from the publication of two parallel …

Cell penetrating peptide: A potent delivery system in vaccine development

B Hasannejad-Asl, F Pooresmaeil… - Frontiers in …, 2022 - frontiersin.org
One of the main obstacles to most medication administrations (such as the vaccine
constructs) is the cellular membrane's inadequate permeability, which reduces their …